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Because of this, you should never combine alcohol and diphenhydramine and drive, operate machinery or be in any potentially risky or unfamiliar situation. It can cause myriad health problems, including cirrhosis of the liver, birth defects, heart disease, stroke, psychological problems, and dementia. Personalized drug interactions checker What side effects people like you reported about your drugs and supplements? Get personalized answers by studying 804 million drug outcomes from FDA, free and anonymous. Compare Dramamine vs Meclizine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Dramamine (Meclizine) Oxybutynin; Silenor (Doxepin) Zyprexa (Olanzapine) Antidepressants: Some drugs used to treat depression like Doxepin (a tricyclic antidepressant) may contain anticholinergic properties. 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